Which neurological symptom can result from TCA overdose?

Which neurological symptom can result from TCA overdose?

• A. Seizures
• B. Coma
• C. Loss of consciousness
• D. Paralysis

Answer: (A)

In the context of tricyclic antidepressant (TCA) overdose, seizures are a well-documented neurological symptom. TCAs can lower the seizure threshold, meaning they make seizures more likely to occur, particularly in overdose situations. This is due to their ability to interfere with neurotransmitter systems in the brain, which can lead to neurological excitability and result in convulsions. While other neurological symptoms can occur in cases of TCA overdose, such as coma and loss of consciousness, seizures specifically highlight the pharmacological mechanisms at play with TCAs, marking them as a significant concern in the event of overdose. Paralysis is not typically associated with TCA toxicity, making seizures the most relevant answer in this scenario.

In the context of tricyclic antidepressant (TCA) overdose, seizures are a well-documented neurological symptom. TCAs can lower the seizure threshold, meaning they make seizures more likely to occur, particularly in overdose situations. This is due to their ability to interfere with neurotransmitter systems in the brain, which can lead to neurological excitability and result in convulsions.

While other neurological symptoms can occur in cases of TCA overdose, such as coma and loss of consciousness, seizures specifically highlight the pharmacological mechanisms at play with TCAs, marking them as a significant concern in the event of overdose. Paralysis is not typically associated with TCA toxicity, making seizures the most relevant answer in this scenario.