Which chromosomal translocation is associated with Chronic Myeloid Leukemia (CML)?

Which chromosomal translocation is associated with Chronic Myeloid Leukemia (CML)?

• A. t(15:17)
• B. t(9:22)
• C. t(8:14)
• D. t(11:22)

Answer: (B)

The translocation associated with Chronic Myeloid Leukemia (CML) is t(9:22). This specific translocation leads to the formation of the Philadelphia chromosome, a hallmark of CML. The translocation occurs between chromosomes 9 and 22, resulting in the fusion of the BCR gene on chromosome 22 with the ABL gene on chromosome 9. This fusion gene, known as BCR-ABL, produces a tyrosine kinase that promotes cell proliferation and inhibits apoptosis, contributing to the pathogenesis of CML. In the context of other translocations mentioned, t(15:17) is typically associated with Acute Promyelocytic Leukemia (APL), t(8:14) is linked with Burkitt Lymphoma, and t(11:22) is connected to Ewing sarcoma. Each of these translocations is indicative of different types of hematologic malignancies or solid tumors and does not play a role in the development of CML.

The translocation associated with Chronic Myeloid Leukemia (CML) is t(9:22). This specific translocation leads to the formation of the Philadelphia chromosome, a hallmark of CML. The translocation occurs between chromosomes 9 and 22, resulting in the fusion of the BCR gene on chromosome 22 with the ABL gene on chromosome 9. This fusion gene, known as BCR-ABL, produces a tyrosine kinase that promotes cell proliferation and inhibits apoptosis, contributing to the pathogenesis of CML.

In the context of other translocations mentioned, t(15:17) is typically associated with Acute Promyelocytic Leukemia (APL), t(8:14) is linked with Burkitt Lymphoma, and t(11:22) is connected to Ewing sarcoma. Each of these translocations is indicative of different types of hematologic malignancies or solid tumors and does not play a role in the development of CML.